GTx acknowledged today that its sole clinical-phase drug candidate enobosarm has failed a Phase II trial in women with stress urinary incontinence—a failure that sent shares free-falling more than 90% back in september—but stopped short of saying whether it will halt the trial or end clinical development of the drug as a result.

enobosarm has failed a Phase II trial in women with stress urinary incontinence


For a long time, S4 was believed to be the answer that researchers have  been creating, the perfect selective androgen receptor modulator that could prevent muscle wasting and reduce the risk of prostate gland enlargement. Phase one human clinical trials happened. The results were said to be extremely positive. Everything was really good, And then suddenly the trials were dropped in favor of a more effective sarm called Enobosarm, also known as ostarine, MK2866, for any chemical to cancel something as potent as S4 , had to be pretty amazing

It is one of the most effective SARMs that you can research, often called by bodybuilders, the perfect sarm, In fact, most researchers compare the results of what you can get with testosterone. It also has the distinction of being the only sarm to have been researched multiple times on humans, but what does it bring to the table for an athlete, a bodybuilder or an amateur trying to break their threshold. Let’s find out what is ostarine mk 2866  aka gt X 024, or a sarm that is developed and researched by gt x laboratories, as a potential therapeutic chem to prevent muscle wasting caused due to cancer. As we briefly mentioned, it has been extensively studied by multiple research agencies. In fact, GTS still has studies underway on and that’s after more than a decade and a half later. That in itself speaks volumes about its perceived potential as therapeutic and gives us a chance one day that it might replace a lot of side effect inducing medicines that we use, but if not for the bodybuilding community,ostarine would be an unknown research chemical at best, bodybuilders started to tap into it way back in the early 2000s. Once the research data became public, and since then it has remained one of the most popular songs in the world. Professional sporting organizations has banned ostarine, way back in 2008 labeling it and as an anabolic agent, wow!

How does work in the body, ostarine binds to specific androgen receptors and muscle and bone tissue, androgen receptors are programmed to receive information about steroidal hormones like testosterone and estrogen by stimulating these receptors, ostarine mimics the action of exogenous testosterone in the body. Think of it like a milder testosterone cycle, without the estrogen and DHD related side effects that most users  don’t want to mess with. It has excellent bio availability, much like it’s sibling (S4 adrenaline).

What are the effects of ostarine? any chemical that is being researched for preventing muscle wasting and muscular dystrophy will find users and abusers they  will use it for increasing muscle mass. That’s the most obvious effect of ostarine is  lean bulk, in a clinical trial that lasted 12 weeks, 120 healthy but elderly individuals were given a surprisingly low dose of ostarine, they gained lean muscle mass and reported an overall improvement in their fitness levels, the dose was just three milligrams a day, bodybuilders use up to 25 milligrams a day and have reported getting up to eight pounds of clean hard muscle in a 12 week cycle. That’s results that most people would live with any day gains that you can keep.

Another unique trait of ostarine reported by users, is that the gains that you make, are more or less permanent, you will lose very little of what you gained during the 12 week cycle. That makes it one of the best off steroids cycle drugs or post PCT supplements that you can use.

Improved bone health. With age, our bodies produce lesser and lesser testosterone, ostarine helps improve bone strength and bone density, which in turn reduces the risk of factors. Ostarine helps to reduce LDL and triglycerides. The only eyebrow raiser is that it may also reduce HDL levels, which is beneficial cholesterol. Having said that, in many steroids cycles triglyceride levels are a major cause for concern. Insulin resistance, ostarine may one day be a safer alternative for anti diabetes drugs like Metformin. It helps improve insulin resistance and reduces blood sugar levels, how to use Austrian.

The recommended dose of ostarine is 25 milligrams per day for a bulking or a cutting cycle and men, women can use a lower dose of up to 10 milligrams a day.

If you are on a body composition cycle then a slightly lower dose of say 15 to 20 milligrams per day might also suffice.

ostarine can be stacked with almost any other song or anabolic steroids, due to its well rounded profile. You can also use it as a PCT drug or in between steroids cycles to maintain the harder and muscle. A typical ostarine muscle building cycle last 12 weeks. There might be minimal suppression, but it’s not severe enough to warrant a full fledged PCT.

Also, if researching using extremely high doses like 40 milligrams a day, not recommended, then you might want to club it with an AI like Arimidex, especially if you’re sensitive to estrogen related sides.

What are the side effects of ostarine

The side effects of Austrian that have been reported by users are generally mild and temporary like lower back pain, low energy headaches and nausea . Some women who have reported menstrual imbalances at high doses. Others have had sporadic acne outbreaks.

To sum it up, ostarine is one of the most promising sarms that have been discovered in recent times. Moreover, it fits right into just about any body building program. Being a bulking cycle of cutting cycle or PCT cycle or body composition. It allows you to gain lean hard muscle that you can keep, even when you discontinue the cycle. It boosts energy, improve heart health and brings about an overall improvement in your quality of life  and it can be stacked with other sarms or steroids. The only thing worth a special mention is that ostarine, like most other sarm should be purchased from reputed sources, o you want a trustworthy supplier ships authentic ostarine.

Does Ostarine have side effects?

One of the most common side effects of Ostarine include feeling hot and sweaty after you take it. You may also find its taste awful, but a glass of orange juice after taking it would help. Another couple side effects include disrupted sleep and a touch of lethargy.


Selective androgen receptor modulators (SARMs) bind to the AR and demonstrate osteo- and myo-anabolic activity; however, unlike testosterone and other anabolic steroids, these nonsteroidal agents produce less of a growth effect on prostate and other secondary sexual organs. SARMs provide therapeutic opportunities in a variety of diseases, including muscle wasting associated with burns, cancer, or end-stage renal disease, osteoporosis, frailty, and hypogonadism. This review summarizes the current standing of research and development of SARMs, crystallography of AR with SARMs, plausible mechanisms for their action and the potential therapeutic indications for this emerging class of drugs.


Urine Screening

Ostarine has become extremely popular. Many professional athletes seek its muscle-building and endurance-enhancing benefits. Anti-doping agencies are well-aware of this and are always developing new ways to screen for SARMs like Ostarine in the urine. More precise screening tests make it hard for any professional athlete to get away with using Ostarine

The side effects users reported include the following:

  • No increases in muscle size or strength after 5 weeks
  • Decreased sense of wellness after the first 9 days
  • Testicle Pain
  • Joint pain
  • Reduced strength
  • Testosterone suppression 4 weeks after stopping it (didn’t do PCT)
  • Erection difficulties
  • Disrupted sleep
  • Low energy
  • Depression
  • Increased estrogens with high doses
  • Menstrual cycle imbalances
  • Acne and skin changes with higher doses
  • Headaches
  • Nausea
  • Baldness
  • Although uncommon, some users do report gyno flare ups. One side of the nipple can become slightly enlarged and painful. Sometimes both nipples are affected.

Again, it’s unknown if some of the users also took steroids, other drugs, or what the Ostarine content in their product was.

With the goal of minimizing estrogens and the detrimental effects on testosterone short- and long-term, most bodybuilders start PCT right after an Ostarine cycle. PCT (Post-Cycle Therapy) consists of anti-estrogens (like Clomid, Nolvadex), which are usually taken for 3 – 4 weeks.

Users who are more sensitive to estrogen or those using high doses (35 mg/day) combine it with aromatase inhibitors (inhibitor like Anastrozole/Arimidex), which prevent the conversion of androgens to estrogen.

The opinions are mixed when it comes to PCT. Some don’t feel the need for it after Ostarine, especially with lower doses (approximately 10 mg/day). Others consider both anti-estrogens and aromatase inhibitors a must after Ostarine cycles. Users who check their labs and see increased estrogens start aromatase inhibitors during a cycle.